Study: Stem cells from strangers can repair hearts

LOS ANGELES (AP) — Researchers are reporting a key advance in using stem cells to repair hearts damaged by heart attacks. In a study, stem cells donated by strangers proved as safe and effective as patients' own cells for helping restore heart tissue.

The work involved just 30 patients in Miami and Baltimore, but it proves the concept that anyone's cells can be used to treat such cases. Doctors are excited because this suggests that stem cells could be banked for off-the-shelf use after heart attacks, just as blood is kept on hand now.

Results were discussed Monday at an American Heart Association conference in California and published in the Journal of the American Medical Association.

The study used a specific type of stem cells from bone marrow that researchers believed would not be rejected by recipients. Unlike other cells, these lack a key feature on their surface that makes the immune system see them as foreign tissue and attack them, explained the study's leader, Dr. Joshua Hare of the University of Miami.

The patients in the study had suffered heart attacks years earlier, some as long as 30 years ago. All had developed heart failure because the scar tissue from the heart attack had weakened their hearts so much that they grew large and flabby, unable to pump blood effectively.

Researchers advertised for people to supply marrow, which is removed using a needle into a hip bone. The cells were taken from the marrow and amplified for about a month in a lab at Baltimore's Johns Hopkins University, then returned to Miami to be used for treatment, which did not involve surgery.

The cells were delivered through a tube pushed through a groin artery into the heart near the scarred area. Fifteen patients were given cells from their own marrow and 15 others, cells from strangers.

About a year later, scar tissue had been reduced by about one-third. Both groups had improvements in how far they could walk and in quality of life. There was no significant difference in one measure of how well their hearts were able to pump blood, but doctors hope these patients will continue to improve over time, or that refinements in treatment will lead to better results.

The big attraction is being able to use cells supplied by others, with no blood or tissue matching needed.

"You could have the cells ready to go in the blood bank so when the patient comes in for a therapy — there's no delay," Hare said. "It's also cheaper to make the donor cells," and a single marrow donor can supply enough cells to treat as many as 10 people.

Dr. Elliott Antman of Harvard-affiliated Brigham and Women's Hospital in Boston who heads the heart conference, praised the work.

"That opens up an entire new avenue for stem cell therapy, like a sophisticated version of a blood bank," he said. There's an advantage in not having to create a cell therapy for each patient, and it could spare them the pain and wait of having their own marrow harvested, he said.

The study was sponsored by the National Institutes of Health. Hare owns stock in a biotech company working on a treatment using a mixture of cells.

Juan Lopez received his own cells in the study, and said it improved his symptoms so much that at age 70, he was able to return to his job as an engineer and sales manager for a roofing manufacturer and ride an exercise bike.

"It has been a life-changing experience," said Lopez, who lives in Miami. "I can feel day by day, week by week, month by month, my improvement. I don't have any shortness of breath and my energy level is way up there. I don't have any fluid in my lungs."

And, he said happily, "My sex drive has improved!"

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP .

___

Online:

Heart Association: http://www.heart.org

JAMA: http://www.jama.ama-assn.org

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My plea to the undecided: Stay home!

By Jeff Greenfield

As the momentous day approaches, with epochal consequences for an anxiously awaiting world, I take pen in hand—make that apply fingertips to keypad—to renew a traditional plea I first made more than 30 years ago. It’s a plea I’ve made in print, on the air and, now, through the miracle of digital technology. But its message never changes.

It’s a plea directed to those of you who are still uncertain about which way to vote. And it’s as simple as it is heartfelt: Stay home.

The candidates have been at this for years; both President Obama and Mitt Romney began running for the presidency six years ago. They’ve made speeches, answered (or evaded) questions and raised billions to convince you of their worth—or the other guy’s worthlessness.

The media have been covering their every move and word, even when the candidates thought they weren’t. (Can you say, “Cling to their religion and guns”? “47 percent”?) The coverage has been slanted, scrupulously fair, superficial, in-depth, misleading, dead-on. With the flip of a page or the click of a mouse, you have been able to find out every conceivable piece of information you might want on their backgrounds, families, values, experience, positions taken, positions abandoned, promises made, promises broken, and the music on their iPods.

And after all this time, you’re still trying to make up your minds. The overwhelmingly likely reason is this: You have the reasoning power of a baked potato.

OK, I grant that you may be of the small minority of concerned citizens who are genuinely torn and who have not yet evaluated the relative worth of health care reform notions, the vagaries of the tax proposals or the respective approaches to the increasing power of the renminbi.

But I wouldn’t bet a nickel on it.

The odds are, you’ve just been too busy obsessing about the misfortunes of the Kardashians or the quality of your ringtone, to spend any time thinking about who might be the better president.

Well, that’s your right. Unlike the Australians, we don’t compel people to vote, and it would likely be a First Amendment violation if we tried. A refusal to vote can be seen as a statement that the electoral system is rigged, meaningless or so thoroughly corrupt as to deserve contempt. (“I never vote,” one citizen said long ago. “It only encourages them.”)

And there are other valid reasons for not voting. As a personal matter, I stopped voting more than a decade ago, on the grounds that it helped me as an analyst not to think about making a choice in the voting booth.

So it strikes me as a sound, honest statement for a prospective voter to say: “Look, I haven’t given this election a minute’s thought, and it’s just not fair for me to cancel out the vote of someone who actually gives a damn.”

Indeed, it’s not just sound and honest—it’s the ethically responsible thing to do.

Men and women in my lifetime have died fighting for the right to vote: people like James Chaney, Andrew Goodman and Michael Schwerner, who were murdered while registering black voters in Mississippi in 1964, and Viola Liuzzo, who was murdered by the Ku Klux Klan in 1965 during the Selma march for voting rights. In these days of early voting, we’ve seen people waiting in line for hours to exercise the franchise. Countless others, who have never had to fight for it, have spent real time either trying to decide how to cast their vote or donating their time to persuading others.

So if you’re one of those folks who have stayed utterly disengaged through all of this, do the honorable thing: Honor those for whom the vote really matters by staying home.

You’ll be doing yourself—and the country—a favor.

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Google's Android software in 3 out of 4 smartphones

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China's Communists endorse Bo Xilai's expulsion

BEIJING (AP) — China's ruling Communist elite have endorsed the expulsion of former high-flying politician Bo Xilai and approved final preparations for the party's upcoming congress, state media reported Sunday.

The closed-door meeting of the Central Committee that ended Sunday was the last before Communist Party leader Hu Jintao and others in his government begin to cede power to Vice President Xi Jinping and others at the congress, which opens Thursday.

The official Xinhua News Agency said the committee endorsed decisions to expel Bo and former Railways Minister Liu Zhijun from the Communist Party. Bo is accused of a range of misdeeds including covering up his wife's murder of a British businessman. Liu faces corruption charges.

The policy-setting committee also appointed two new vice chairmen of the Central Military Commission, Xinhua said.

The Central Committee is comprised of about 370 people from the upper ranks of the party, government and military.

Bo's ouster earlier this year widened rifts within a leadership that likes to project an image of unity. It also complicated the bargaining over the roster of new leaders.

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Lucas plans 'little personal films' in future

NEW YORK (AP) — George Lucas is done with "Star Wars," but not with filmmaking.

The "Star Wars" creator says he's looking forward to making his "own little personal films" that he doubts will be for the theater crowd.

Lucas spoke Friday night at Ebony magazine's Power 100 Gala, days after announcing the sale of his storied Lucasfilm to Disney for $4.05 billion. The deal would allow for more "Star Wars" films.

Lucas was "very sad" let Lucasfilm go but excited about his educational foundation, which will benefit from the sale. He also plans to make more movies. His last one was this year's "Red Tails," about the Tuskegee Airmen, but he said he barely got it in theaters. He said the movies he's working on now "will never get into theaters."

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Floods render NYC hospitals powerless

NEW YORK (AP) — There are few places in the U.S. where hospitals have put as much thought and money into disaster planning as New York. And yet two of the city's busiest, most important medical centers failed a fundamental test of readiness during Superstorm Sandy this week: They lost power.

Their backup generators failed, or proved inadequate. Nearly 1,000 patients had to be evacuated.

The closures led to dramatic scenes of doctors carrying patients down dark stairwells, nurses operating respirators by hand, and a bucket brigade of National Guard troops hauling fuel to rooftop generators in a vain attempt to keep the electricity on.

Both hospitals, NYU Langone Medical Center and Bellevue Hospital Center, were still trying to figure out exactly what led to the power failures Thursday, but the culprit appeared to be the most common type of flood damage there is: water in the basement.

While both hospitals put their generators on high floors where they could be protected in a flood, other critical components of the backup power system, such as fuel pumps and tanks, remained in basements just a block from the East River.

Both hospitals had fortified that equipment against floods within the past few years, but the water — which rushed with tremendous force — found a way in.

"This reveals to me that we have to be much more imaginative and detail-oriented in our planning to make sure hospitals are as resilient as they need to be," said Irwin Redlener, director of the National Center for Disaster Preparedness at Columbia University's Mailman School of Public Health.

The problem of unreliable backup electricity at hospitals is nothing new.

Over the first six months of the year, 23 percent of the hospitals inspected by the Joint Commission, a health care facility accreditation group, were found to be out of compliance with standards for backup power and lighting, according to a spokesman.

Power failures crippled New Orleans hospitals after Hurricane Katrina. The backup generator failed at a hospital in Stafford Springs, Conn., after the remnants of Hurricane Irene blew through the state in 2011. Hospitals in Houston were crippled when Tropical Storm Allison flooded their basements and knocked out electrical equipment in 2001.

When the Northeast was hit with a crippling blackout in 2003, the backup power at several of New York City's hospitals failed or performed poorly. Generators malfunctioned or overheated. Fuel ran out too quickly. Even where the backup systems worked, they provided electricity to only some parts of the hospital and left others in the dark.

Afterward, a mayoral task force recommended upgrading testing standards for generators and requiring backup plans for blood banks and health care facilities that provide dialysis treatment.

Alan Aviles, president of New York City's Health and Hospitals Corp., which operates Bellevue, said that after a scare last summer when Hurricane Irene threatened to cause flooding, Bellevue put its basement-level fuel pumps in flood-resistant chambers.

It still isn't clear whether water breached those defenses, but when an estimated 17 million gallons of water rushed through loading docks and into the hospital's 1-million-square-foot basement, the fuel feed to the generators stopped working. The floodwaters also knocked out the hospital's elevators.

For two days, National Guardsmen carried fuel to the generators, but conditions inside the hospital for patients and staff deteriorated anyway. The generators were designed to supply only 30 percent of the usual electrical load at the hospital, leaving a lot of equipment and labs hobbled. The hospital also lost all water pressure on Tuesday. Nearly 700 patients had been evacuated by Thursday afternoon.

"The precautions we had taken to date had served us well," Aviles said. "But Mother Nature can always up the stakes."

NYU Langone Medical Center had also tried to armor itself against floods.

All seven of the generators providing backup power to the parts of the hospital involved in patient care are only a few years old and are on higher floors. The fuel tank is in a watertight vault. New fuel pumps were installed just this year in a pump house upgraded to withstand a high flood, said the hospital's vice president of facilities operation, Richard Cohen.

"The medical center invested quite a bit of money to upgrade the facility," he said.

The pump house remained "bone dry," Cohen said. But water shoved aside plastic and plywood defenses and infiltrated the fuel vault, where sensors detected the potentially damaging liquid and shut the generators down. "The force of the surge that came in was unbelievable. It dislodged our additional protection and caused a breach of the vault as well," Cohen said.

The power at NYU went out in a flash, leaving the staff scrambling to evacuate 300 patients with no notice.

Dr. Robert Berg, an obstetrician, said that when he lost power in his apartment, he went to the hospital to charge his cellphone and was stunned to find it in chaos.

"It didn't really occur to me that the hospital was going to be in trouble," he said. Even after finding the lobby dark, "I thought, 'We'll have power upstairs. We're an operating room.'"

He wound up carrying two patients down flights of stairs on a "med sled."

"There was a Category 1 outside and a Category 4 inside," he said. "I can't say that they were very well prepared for it."

That has left only one hospital, Beth Israel Medical Center, functioning in the southern third of Manhattan. It is also on backup power, but brought in two huge new generators Thursday, just in case.

Aviles said Bellevue might be out of commission for at least two more weeks. NYU Langone's generators are operating again, but the hospital is waiting for Consolidated Edison to restore its power before it starts taking patients again. That could happen in a matter of days.

Flooding may pose less of a danger to the hospital's power supply in the future. Construction is under way on a new power plant, at a cost of more than $200 million, that will run on natural gas and supply all the hospital's power needs.

"It's a tremendous facility, with a lot of hardening built into it," Cohen said.

___

AP Medical Writer Mike Stobbe contributed to this report.

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Florida's I-4 corridor: The mother road of swing voters

By Bob Sacha and Maisie Crow


Interstate 4 bisects the center of America's most notorious swing state, running 132 miles from Tampa, through Orlando and ending near Daytona Beach. Fifty-five percent of Florida voters live in the I-4 corridor. It is often where elections are decided in a state that has frequently switched sides, voting for Republicans seven times and Democrats three times in the past 10 elections, and voting for the winning presidential candidate 90 percent of that time.


For the final installment of our Road Trip video series for Campaign 2012, Yahoo News headed to Florida in search of the exotic, perhaps mythical, undecided voter. Here are three of our conversations.


'I have been registered to vote for seven years, and I have never voted.'



In a state filled with colorful characters, Eve Banks, 25, entertains many of them at the Mons Venus club in Tampa. She also travels extensively for her work as an exotic dancer. Eve Banks is a stage name: "I don't want girls from my sorority looking me up online," she says.


"I'm living a version of the American dream," she told Yahoo News. "It's not like the white picket fence, but I do have the dogs and I do have the husband. And I have everything I want. It's just kind of a different way of achieving it."


In the 2012 presidential election, Banks will be voting for the first time, casting a ballot for Barack Obama, she says, because of his support for women. "I generally don't care about politics because I feel like little old me does not make a difference," she said. "But this year I think is a lot different than previous years because of what's at stake right now.


"There was a lot of discrimination against women, believe it or not, not even that long ago really if you think about it. And that'll all change if we don't put the right person in the position," Banks said. "No woman wants a government to control her body or her choices."


'It has gotten pretty ugly between the two. I'm not sure I would want to be a part of it.'



Lloyd Parker, 33, hasn't decided how he is going to vote. He was working for a land development company in Lake Tahoe in Nevada until business started to slow down. His best friend lured him to Florida to become an entrepreneur by starting the Savage Race, an obstacle race in the mud. We hung out with him during their third race in Dade City.


"The Savage Race is a four- to six-mile mud obstacle course," Parker said. "It's timed. Twenty to 25 military-style obstacles that challenge you in many different ways. And afterward it's a fun gathering with live music and a party atmosphere."


Parker called Florida a Savage Race of sorts for Obama and Mitt Romney: "It is everywhere. It seems to be all over Facebook, everything. Maybe that has turned me off a little bit. That it's just been too much of back and forth and negativity, and it probably pushed me away a little bit.


"I have not been following it very much lately," he told Yahoo News. "In the last month I have been extremely busy with this course. I'm out on a ranch with no cable."


'I think somebody that's been in the farming business as long as we have—I don't think we should have to pay any inheritance tax.'



When Dave Black, 73, started in the citrus-farming and ranching business 42 years ago in Clermont, he stood on his 22 acres and saw fruit trees everywhere. Now his property is down to 14 acres, and it is hemmed in by new housing developments on three sides.


"We've got enough houses," Black told Yahoo News. "I mean we should leave a little open space."


Black is voting for Romney because of his opposition to the inheritance tax, in the hope that he can pass his property to his children undivided and tax-free.


"The Electoral College, I don't care for," he said. "I want the people to decide, not this state or that state. You know, Bush, the first election, he won on electoral votes. He didn't win on popular votes. Gore beat him on popular votes. So, that's wrong. That's just my opinion."


Bob Sacha is a multimedia producer, a documentary filmmaker, a photojournalist and a teacher. Maisie Crow is a documentary photographer, a filmmaker and a visual storytelling teacher. Earlier this year, Bob Sacha and Zach Wise traveled to Nevada to talk to Hispanics about the presidential election. In October, they talked to small-business owners along Colorado's Colfax Avenue. In July, Bob Sacha and Miki Meek traveled to Northern Virginia to talk to Mormons about what a President Romney would mean to them. In March, they drove Ohio's I-71 and talked to Republicans before Super Tuesday.


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Google's Android software in 3 out of 4 smartphones

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As foreigners go, Afghan city is feeling abandoned

KANDAHAR, Afghanistan (AP) — By switching from studying business management to training as a nurse, 19-year-old Anita Taraky has placed a bet on the future of the southern Afghan city of Kandahar — that once foreign troops are gone, private-sector jobs will be fewer but nursing will always be in demand.

Besides, if the Taliban militants recapture the southern Afghan city that was their movement's birthplace and from which they were expelled by U.S.-led forces 11 years ago, nursing will likely be one of the few professions left open to women.

Taraky is one of thousands of Kandaharis who are weighing their options with the approaching departure of the U.S. and its coalition partners. But while she has opted to stay, businessman Esmatullah Khan is leaving.

Khan, 29, made his living in property dealing and supplying services to the Western contingents operating in the city. Property prices are down, and business with foreigners is already shrinking, so he is pulling out, as are many others, he said.

Many are driven by a certainty that the Taliban will return, and that there will be reprisals.   

"From our baker to our electrician to our plumber, everyone was engaged with the foreign troops and so they are all targets for the Taliban. And unless the government is much stronger, when the foreign troops leave, that is the end," Khan said.

The stakes are high. Kandahar, Afghanistan's second city, is the southern counterweight to Kabul, the capital. Keeping Kandahar under central government control is critical to preventing the country from breaking apart into warring fiefdoms as it did in the 1990s.

"Kandahar is the gate of Afghanistan," said Asan Noorzai, director of the provincial council. "If Kandahar is secure, the whole country is secure. If it is insecure, the whole country will soon be fighting."

Even though Kandahar city has traffic jams and street hawkers to give it an atmosphere of normality, there are dozens of shuttered stores on the main commercial street, it's almost too easy to find a parking space these days, and shopkeepers are feeling the pinch.

Dost Mohammad Nikzad said his profits from selling sweets have dropped by a half or more in the past year, to about $30 a day, and he has had to cut back on luxuries.

He said that every month he would buy a new shalwar kameez, the tunic favored by Afghan men; now he buys one every other month.

"I only go out to eat at a restaurant once a week. Before I would have gone multiple times a week," Nikzad said, as he stood behind his counter, waiting for customers to show.

The measurements of violence levels contradict each other. On the one hand, many Kandaharis say things are better this year. On the other hand, the types of violence have changed and, to some minds, gotten worse.

"Before, we were mostly worried about bomb blasts. Now ... we are afraid of worse things like assassinations and suicide attacks," said Gul Mohammad Stanakzai, 34, a bank cashier.

Prying open the Taliban grip on Kandahar and its surrounding province has cost the lives of more than 400 international troops since 2001, and many more Afghans, including hundreds of public officials who have been assassinated by the Taliban.

Kandahar province remains the most violent in the country, averaging more than five "security incidents" a day, according to independent monitors. In Kandahar city, suicide attacks have more than doubled so far this year compared with the same period of 2011, according to U.N. figures.

"They are not fighting in the open the way they were before. Instead they are planting bombs and trying to get at us through the police and the army," said Qadim Patyal, the deputy provincial governor.

The Taliban have said in official statements that they are focusing more on infiltrating Afghan and international forces to attack them. In the Kandahar governor's office, armed Afghan soldiers are barred from meetings with American officials lest they turn on them, Patyal said.

And many point out that the "better security" is only relative. By all measures — attacks, bombings and civilian casualties — Kandahar is a much more violent city now than in 2008, before U.S. President Barack Obama ordered a troop surge.

There are no statistics on how many people have left the city of 500,000, but people are fleeing the south more than any other part of the country, according to U.N. figures. About 32 percent of the approximately 397,000 people who were recorded as in-country refugees were fleeing violence in the south, according to U.N. figures from the end of May.

The provincial government, which is supposed to fill the void left by the departing international forces, has suffered heavily from assassinations. It suffered a double blow in July last year with the killing of Ahmed Wali Karzai, the half-brother of President Hamid Karzai who was seen as the man who made things work in Kandahar, and Ghulam Haider Hamidi, the mayor of the city.

Now, Noorzai says, he can neither get the attention of ministers in Kabul nor trust city officials to do their jobs.

He remembers 2001, when he and others traveled to the capital flying the Afghan flag which had just been reinstated in place of that of the ousted Taliban. "People were throwing flowers and money on our car, they were so happy to have the Afghan flag flying again," he said.

"When we got power, what did we give them in return? Poverty, corruption, abuse."

Mohammad Omer, Kandahar's current mayor, insists that if people are leaving the city, it is to return to villages they fled in previous years because now security has improved.

Zulmai Hafez disagrees. He has felt like a marked man since his father went to work for the government three years ago, and is too frightened to return to his home in the Panjwai district outside Kandahar city. He refused to have his picture taken or to have a reporter to his home, instead meeting at the city's media center.

"It's the Taliban who control the land, not the government," Hafez said. He notes that the government administrator for his district sold off half his land, saying he would not be able to protect the entire farm from insurgents. Many believe the previous mayor was murdered because he went after powerful land barons.

Land reform is badly needed, and the mayor is angry about people who steal land, but he offers no solution. Kandahar only gets electricity about half the day. The mayor says it's up to the Western allies to fix that. But the foreign aid is sharply down. Aid coming to Kandahar province through the U.S. Agency for International Development, the largest donor, has fallen to $63 million this year from $161 million in 2011, according to U.S. Embassy figures.

The mayor prefers to talk about investing in parks and planting trees. "I can't resolve the electricity problem, but at least I can provide a place in the city for people to relax," he said.

The only people thinking long-term appear to be the Taliban.

"The Americans are going and the Taliban need the people's support, so they are trying to avoid attacks that result in civilian casualties," said Noor Agha Mujahid, a member of the Taliban shadow government for Kandahar province, where he oversees operations in a rural district. "After 2014 ... it will not take a month to take every place back."

One of the biggest worries is the fate of women who have made strides in business and politics since the ouster of the Taliban.

"What will these women do?" asked Ehsanullah Ehsan, director of a center that trains more than 800 women a year in computers, English and business. It was at his center where Anita Taraky studied before switching to nursing.

"Even if the Taliban don't come back, even if the international community just leaves, there will be fewer opportunities for women," he said.

On the outskirts of the city stands one of the grandest projects of post-Taliban Kandahar — the gated community of Ayno Maina with tree-lined cement homes, wi-fi and rooftop satellite dishes.

Khan, the departing businessman, says he bought bought 10 lots for $66,000 in Ayno Maina and has yet to sell any of them despite slashing the price,

He recalled that when he first went to the project office it was packed with buyers. "Now it is full of empty houses. No one goes there," Khan said.

Only about 15,000 of the 40,000 lots have been sold, and 2,400 homes built and occupied, according to Mahmood Karzai, one of the development's main backers and a brother of President Karzai. He argues, however, that prices are down all over Afghanistan, and that Ayno Maina is still viable, provided his brother gets serious about reform that will attract investors.

"Afghanistan became a game," he said over lunch at the Ayno Maina office. "The game is to make money and get the hell out of here. That goes for politicians. That goes for contractors."

He shrugged off allegations that he skimmed money from Ayno Maina, saying the claims were started by competitors in Kabul who assume everyone who is building something in Afghanistan is also stealing money.

He said the money went where it was needed: to Western-style building standards and security.

In downtown Kandahar, a deserted park and Ferris wheel serve as another reminder of thwarted hopes. Built in the mid-2000s, the wheel has been idle for two years according to a guard, Abdullah Jan Samad. It isn't broken, he said, it just needs electricity. A major U.S.-funded project to get reliable electricity to the city has floundered and generators that were supposed to provide a temporary solution only operate part-time because of fuel shortages.

"The government should be paying for maintenance for the Ferris wheel," the guard said. "When you build something you should also make sure to maintain it."

____

Associated Press Writer Mirwais Khan contributed to this report from Kandahar.

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George Lucas' filmmaking rooted in rebellion

LOS ANGELES (AP) — There's no mistaking the similarities. A childhood on a dusty farm, a love of fast vehicles, a rebel who battles an overpowering empire — George Lucas is the hero he created, Luke Skywalker.

His filmmaking outpost, Skywalker Ranch, is so far removed from the Hollywood moviemaking machine he once despised, that it may as well be on the forest moon of Endor.

That's why this week's announcement that Lucas is selling the "Star Wars" franchise and the entire Lucasfilm business to The Walt Disney Co. for more than $4 billion is like a laser blast from outer space.

Lucas built his film operation in Marin County near San Francisco largely to avoid the meddling of Los Angeles-based studios. His aim was to finish the "Star Wars" series— his way.

Today the enterprise has far surpassed the 68-year-old filmmaker's original goals. The ranch covers 6,100 acres and houses one of the industry's most acclaimed visual effects companies, Industrial Light & Magic. Lucasfilm, with its headquarters now in San Francisco proper, has ventured into books, video games, merchandise, special effects and marketing. Just as Anakin Skywalker became the villain Darth Vader, Lucas —once the outsider— had grown to become the leader of an empire.

"What I was trying to do was stay independent so that I could make the movies I wanted to make," Lucas says in the 2004 documentary "Empire of Dreams." ''But now I've found myself being the head of a corporation ... I have become the very thing that I was trying to avoid."

After the blockbuster sale announcement Tuesday, Lucas expressed a desire to give away much of his fortune, donate to educational causes and return to the experimental filmmaking of his youth. Still, the move stunned those who've followed him. He'd contemplated retirement for years and said he'd never make another "Star Wars" film.

Dale Pollock, the author of the 1999 biography "Skywalking," said Lucas disdained the Disney culture in interviews he gave in the 1980s, even though he admired the company's founder. "He felt the corporate 'Disneyization' had destroyed the spirit of Walt," Pollock said.

Lucas said through a spokeswoman on Saturday that he never said such a thing. But his anti-corporate streak is renowned. In the Lucasfilm-sanctioned documentary "Empire of Dreams", Lucas says on camera that he is "not happy that corporations have taken over the film industry."

Growing up in the central California town of Modesto, the independent streak was strong in young Lucas. The family lived on a walnut ranch and Lucas' father owned a stationery store. But, like his fictional protege Luke, George had no interest in taking over the family business. Lucas and his father fought when George made it clear that he'd rather go to college to study art than follow in his father's footsteps.

Lucas loved fast cars, and dreamed that racing them would be his ticket out. A near-fatal car crash the day before his high school graduation convinced him otherwise.

"I decided I'd better settle down and go to school," he told sci-fi magazine Starlog in 1981.

As a film student at the University of Southern California, he experimented with "cinema verite," a provocative form of documentary, and "tone poems" that visualized a piece of music or other artistic work.

The style is reflected in some of the short films he made at USC: "1:42:08" focused on the sound of a Lotus race car's engine driving at full speed and "Anyone Who Lived in a Pretty How Town," inspired by an e.e. Cummings poem. In later interviews, Lucas described his early films as "visual exercises."

Lucas' intellectual explorations led to an interest in anthropology, especially the work of American mythologist Joseph Campbell, who studied the common thread linking the myths of disparate cultures. This inspired Lucas to explore archetypal storylines that resonated across the ages and around the world.

Lucas' epic battle with the movie industry began after Warner Bros. forced him to make unwanted changes to an early film, "THX 1138." Later, Universal Pictures insisted on revisions to "American Graffiti" that Lucas felt impinged on his creative freedom. The experience led Lucas to insist on having total control of all his work, just like Charlie Chaplin and Walt Disney in their heyday.

"In order to get my vision out there, I really needed to learn how to manipulate the system because the system is designed to tear you down and destroy everything you are doing," Lucas said in an interview with Charlie Rose.

He shopped his outline for "Star Wars" to several studios before finding a friend in Alan Ladd Jr., an executive at 20th Century Fox. Despite budget and deadline overruns, and pressure from the studio, the movie was a huge success when it was released in 1977. It grossed $798 million in theaters worldwide and caused Fox's stock price at the time to double.

In one of the wisest business moves in Hollywood history, Lucas cut a deal with distributor Fox before the film's release so that he could retain ownership of the sequels and rights for merchandise. He figured in the 1970s that might mean peddling a few T-shirts and posters to fans to help market the movie. Over the decades, merchandising has formed the bedrock of his multi-billion-dollar enterprise, resulting in a bonanza for Lucas from action figures, toys, spinoff books and other products.

Industrial Light & Magic, the unit he started in a makeshift space in the Los Angeles suburb of Van Nuys, moved to the ranch in northern California and lent its prowess to other movies. It broke ground using computers, motion-controlled cameras, models and masks. Its reach is breathtaking, notably among the biggest science fiction movies of the 1980s: "E.T. The Extra-Terrestrial," ''Poltergeist," ''Back to the Future," ''Indiana Jones and the Raiders of the Lost Ark," ''Star Trek II: The Wrath of Khan" and more.

"Between him and (Steven) Spielberg, they changed how movies got made," said Matt Atchity, editor-in-chief of movie review website Rotten Tomatoes.

These days, the talent at ILM has spread around the globe, and many former employees have become top executives at other special effects companies, said Chris DeFaria, executive vice president of digital production at Warner Bros.

"You meet anybody who's a significant executive or artist at a company, they've spent their time at ILM or got their start there. That's probably one of George's greatest gifts to the business," DeFaria said.

Lucas helped make the tools that were needed for his films. ILM developed the world's first computerized film editing and music mixing technology, revolutionizing what had been a cut-and-splice affair. Pixar, the imaging computer he founded as a division of Lucasfilm, became a world-famous animated movie company. Apple's Steve Jobs bought and later sold it to Disney in 2006.

But the goliath Lucas created began to weigh on him. Fans-turned-critics felt the "Star Wars" prequel trilogy he directed fell short of the first films. Others believed his revisions to the re-released classics undid some of what made the first movies great.

Giving up his role at the head of Lucasfilm may shield him from the fury of rebellious fans and critics. He said in a video released by Disney that the sale would allow him to "do other things, things in philanthropy and doing more experimental kind of films."

"I couldn't really drag my company into that."

Still, Lucas is not planning on going to a galaxy far, far away.

Speaking on Friday night at Ebony magazine's Power 100 event in New York, Lucas said: "It's 40 years of work and it's been my life, but I'm ready to move on to bigger and better things. I have a foundation, an educational foundation. I do a lot of work with education, and I'm very excited about doing that."

This week he assured the incoming president of Lucasfilm, Kathleen Kennedy that he'd be around to advise her on future "Star Wars" movies —just like the apparition of Jedi Knight Obi-Wan Kenobi helps Luke through his adventures.

"They're finishing the hologram now," he told Kennedy. "Don't worry."

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Liedtke reported from San Francisco. Global Entertainment Editor Nekesa Mumbi Moody in New York contributed to this story.

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